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This means that once the patient returns to a normal diet or slightly increases their food intake, the body will burn fewer calories than it consumes, and the excess calories will be converted back into fat accumulation, leading to weight rebound and causing previous weight loss efforts to go to waste
A recent systematic review identified 33 registered trials looking at GLP-1s for SUDs, predominantly for alcohol and nicotine, but with growing interest in opioid and stimulant SUDs
In obesity and metabolic dysfunction, NNMT is often overexpressed in adipose tissue, depleting nicotinamide and lowering NAD+ availability [2]
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