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Mikus et al., 2001
A B12 shot is a quick intramuscular injection of vitamin B12 (cobalamin) that bypasses the stomach acid, liver metabolism, and intestinal absorption issues that limit oral B12 to roughly 1% bioavailability in most adults
Sequential vs simultaneous administration Sequential approach: Start single peptide establishing baseline response and tolerability
And it signals satiety through the area postrema in the brainstem, telling your brain that you have eaten enough
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