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It does not force a biochemical shutdown
Pilewska-Bednarek M, Nakano RT, Hiruma K, Pastorczyk M, Sanchez-Vallet A, Singkaravanit-Ogawa S, Ciesioka D, Takano Y, Molina A, Schulze-Lefert P, Bednarek P (2018) Glutathione transferase U13 functions in pathogen-triggered glucosinolate metabolism
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The appetite decrease is of course part of the intended mechanism, but it can become excessive during aggressive titration, leading to inadequate caloric and protein intake
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