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The 2025 joint advisory from the American College of Lifestyle Medicine, the American Society for Nutrition, the Obesity Medicine Association, and The Obesity Society notes that intakes of 1.2 to 1.6g per kilogram of body weight per day have been proposed during active weight reduction, well above the 0.8g/kg baseline

Tirzepatide (Mounjaro, Zepbound) is an FDA-approved dual GIP/GLP-1 receptor agonist used for type 2 diabetes and chronic weight management

Phiel CJ, Zhang F, Huang EY et al (2001) Histone Deacetylase Is a Direct Target of Valproic Acid, a Potent Anticonvulsant, Mood Stabilizer, and Teratogen

2017;312:F81935