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Peak plasma concentrations may be markedly delayed following acute overdose [1114]
Liraglutide depolarizes membrane potential and increases the spontaneous action potentials directly through postsynaptic GLP-1R in the ARC neurons expressing POMC (Secher et al., 2014
While subjective, this observation aligns with the peptides known mechanisms and provides a tangible indicator that something is happening at the tissue level
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