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It is the most clinically studied of the three, with topical trials showing collagen, fine-line, and skin-density changes, and a large body of in-vitro work on gene expression and wound healing

The glucose-sparing effects of increased fat oxidation further protect lean tissue from catabolism during energy deficit states

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If acne is severe, persistent despite treatment, causing scarring, or significantly affecting your quality of life, request referral to a dermatologist