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Furthermore, studies have shown that mitochondrial-targeted nanodrugs enhance the sensitivity of cancer cells to chemotherapy drugs by intervening in mitochondrial function, further emphasizing the emerging therapeutic strategy of reversing drug resistance through mitochondrial metabolic reprogramming [146]

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Active chemotherapy requires careful timing and medical supervision

There is evidence that combinations of polymorphisms in genes encoding enzymes that metabolize alcohol, including ADH1B*2, ADH1C*1, ALDH2*2 and CYP2E1*5, increase susceptibility to development of liver disease through accumulation of acetaldehyde in the organism