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Its expression is significantly elevated in breast cancer and various other drug-resistant tumors ( - can be activated by several stress conditions, including amino acid deprivation, electrophiles, oxidative stress, glucose starvation, and factors dependent on NRF2 and ATF4 ( - expression by inhibiting SLC7A11, thereby influencing ferroptosis ( - contributing to sorafenibs efficacy in drug-resistant cancers ( - , facilitates the exchange of intracellular glutamate for extracellular cysteine, a process essential for maintaining redox balance and supporting the survival of breast cancer cells

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to knockdown mouse PGM1 is: 5-GGGATTGGTCGCCTGGTTATT-3

However, most people need less