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Elevated levels of reactive oxygen species can activate pro-inflammatory signaling cascades and apoptotic pathways, which in turn exacerbate neuroinflammation, impair neurogenesis, and contribute to synaptic and structural changes implicated in depression (104)

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In addition to their glycemic effects, DPP-4 inhibitors have the potential to decrease bone resorption, increase bone formation, and reduce the incidence of osteoporosis and fractures

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