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The absence of standardized criteria for ovarian dysfunction and poor responder classification limits generalizability across studies, complicating the identification of target populations (Tomita et al., 2023)

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Common approaches include: Morning dosing supports daytime recovery and activity Evening or bedtime injection aligns with natural repair processes during sleep Post-workout administration enhances recovery immediately after training stress Some users report that late-day injections cause sleep disruption, possibly related to nitric oxide system activation

Fits when stress-triggered flushing rides alongside reactive skin