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Proper dosing and monitoring minimize these concerns

found that treatment of WT mice with the exogenous depalmitoylation inhibitor Palm B was able to significantly increase synaptic postsynaptic density protein 95(PSD-95) levels by inhibiting PSD-95 depalmitoylation, which could reverse A-induced synaptic inhibition, but the same manipulation was not effective in PSD-95 knockout (KO) mice