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However, a notable safety signal emerged: dysesthesia (abnormal nerve sensations) was reported in up to 20.9% of patients at the highest dose ( [139] )
(Figura 2)
These preclinical observations in rodents promote continued study with the aim of translation to larger animals and specifically primates, the central focus being the quantification of therapeutic index when administered for sustained periods
But the structural distinctions are sometimes important when examining and comparing individual medications
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