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The study did not show a clinically meaningful change in either hormones exposure: ethinyl estradiol exposure (level) was essentially unchanged, and levonorgestrel exposure (level) increased modestly (by less than 20%), in a way that, if anything, would maintain or improve contraceptive effectiveness
doi: 10.1038/nm919 118 AbbasTFaivreEHolscherC
They are usually taken at night, because the body releases its largest growth hormone pulse during early deep sleep
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