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The damage caused by SAP to the vascular endothelium is manifested as the release of inflammatory mediators and leukocyte adhesion, increased vascular permeability, changes in blood flow shear stress, microthrombosis, and microcirculatory disorders
Mishima E, Nakamura T, Zheng J, Zhang W, Mouro ASD, Sennhenn P, et al
Fact: Higher doses do not matter if the body cannot absorb them
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