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In addition, the treatment of nicotinamide (NAM), a form of vitamin B3, suppressed the activity of sirtuin-1 (SIRT1), a regulator of cellular stress resistance, and peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1), a key transcriptional coactivator involved in mitochondrial biogenesis and energy metabolism
The peptide is metabolized by standard peptidase activity but shows unusual resistance to gastric acid degradation, with stability documented in pH as low as 1.5 for over 24 hours
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