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The cytosolic Ca 2+ response was determined as the change in GCaMP6s fluorescence (FGCaMP6s) from baseline to the maximum post-treatment value and the GCaMP6s area under the curve (AUC) was determined using GraphPad Prisim software
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A near maximum glucose excretion was observed at the dapagliflozin daily dosage of 20 mg
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