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Nevertheless, careful consideration is needed when extrapolating in vitro effective concentrations to realistic in vivo exposure scenarios, as factors such as bioavailability, metabolism, and tissue distribution critically determine the actual dose reaching target organs
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Second, semaglutide activates GLP-1 receptors in the central nervous system, particularly in the brainstem area postrema and nucleus tractus solitarius, regions responsible for nausea and vomiting responses
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