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Beyond its interaction with lipid enzymes, our MS interactome analysis also indicates that the GLP-1R binds to ERMCS-localised Sarcoendoplasmic Reticulum Calcium ATPase (SERCA) pump 88 in the ER and voltage-dependent anion-selective channel protein 2 (VDAC2) in the OMM, both involved in calcium/ion transfer across ERMCSs 89 , suggesting a prominent role for the receptor in the control of intra-organelle ion homeostasis, with important implications for the regulation of mitochondrial function, ER stress responses and insulin secretion 90
Features Semaglutide
10.1080/00365520410010634 46 RebosioC.BalbiM.PassalacquaM.RicciarelliR.FedeleE
Therefore, a KLOW dosage guide developed for young, healthy models might not be appropriate for older or immunocompromised subjects, requiring careful adjustments
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