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This elevation in NAD+ activates SIRT1, a master regulator of metabolic pathways that promotes fat oxidation, enhances mitochondrial function, and improves insulin sensitivity
171,172 In an older randomized placebo-controlled trial in 45 women with fibromyalgia and low levels of IGF-1 (a peptide made in the liver in response to stimulation by growth hormone), those receiving subcutaneous growth hormone injections for nine months had greater reductions in tender points and fibromyalgia impact scores and were more likely to experience global improvement compared with those receiving placebo
Researchers have observed that it stimulates growth hormone release from anterior pituitary somatotrophs without significantly affecting cortisol, prolactin, or adrenocorticotropic hormone (ACTH) levels a selectivity profile that has made it one of the most widely studied GHRPs in preclinical research
Halliwell B, Gutteridge JM
