difference between semaglutide and dulaglutide versus once weekly in patients with type 2 diabetes (SUSTAIN 7): a randomised, open-label, phase 3b trial Semaglutide vs dulaglutide in UK

Am J Physiol Endocrinol Metab (2016) 310(1):E4150

Beyond interaction with lipid enzymes, our MS interactome analysis indicates that the GLP-1R binds to ERMCS-localised Sarcoendoplasmic Reticulum Calcium ATPase (SERCA) pump in the ER and voltage-dependent anion-selective channel protein 2 (VDAC2) in the OMM, both involved in calcium/ion transfer across ERMCSs 90 , suggesting a prominent role for the receptor in the control of intra-organelle ion homoeostasis, with important implications for the regulation of mitochondrial function, ER stress responses and insulin secretion 91

Similarly, patients on insulin or other glucose-lowering medications must coordinate any break with their clinical team to avoid hypoglycemia or hyperglycemia

GLP-1 medications demonstrated notable benefits for male reproductive health and better sperm quality