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(Saying this as someone with a BMI that cutely labels me obese.) So you go to the doctor, step on the scale, say you want to get pregnant and the first thing they tell you is to lose weight

This rapid turnover means that maintaining therapeutic levels of GLP-1 activity requires either continuous endogenous production or pharmaceutical intervention with DPP-4-resistant analogs

GLP-1/GIP agonists: Semaglutide (Wegovy), liraglutide (Saxenda) and tirzepatide (Zepbound) GLP-1 agonists are weight loss medications that cause your stomach to empty more slowly, so you feel full longer

This allows semaglutide therapy to remain aligned with evolving metabolic indicators