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In rare cases, some people may experience gastroparesis, or delayed gastric emptying, in which the stomach takes longer than usual to empty food
This mechanism, however, seems to be unlikely for SOM because the presence of a large number of homogeneously mixed organic compounds in SOM can facilitate the formation of a stable liquid or amorphous state, even in the absence of water 33,34
Importantly, the observed attenuation of incremental benefit at higher doses for both agents suggests diminishing returns with dose escalation, reinforcing the need to balance expected benefit against treatment burden and patient-specific factors
A meta-analysis was done that pooled 76 randomized clinical trials to evaluate the absolute risk of developing cholelithiasis in patients taking GLP1-RAs
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