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FOXO4-DRI (Forkhead Box O4-D-Retro-Inverso) is a rationally designed synthetic peptide that functions as a selective senolytic agent, specifically targeting senescent cells for elimination while leaving healthy cells unharmed

The compound occurs naturally in human plasma at concentrations that decline progressively with age, a feature that has driven decades of research interest

As previously stated, it is needed to produce lecithin for fat breakdown in the blood

184,185,199 Rational combinations, such as PARPis plus ATR or WEE1 inhibitors, aim to exacerbate replication stress and collapse replication fork stability, particularly in tumors with partial or context-specific DDR competence