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Phase 2 NEJM titration (still common in research) Phase 2 retatrutide titration schedule Phase Initiation Weeks Weeks 1-4 Weekly Dose 1 mg Phase Early escalation Weeks Weeks 5-8 Weekly Dose 2 mg Phase Mid escalation Weeks Weeks 9-12 Weekly Dose 4 mg Phase High escalation Weeks Weeks 13-16 Weekly Dose 8 mg Phase Maximum Weeks Weeks 17+ Weekly Dose 12 mg Source: Jastreboff et al., NEJM 2023
Novo, Lilly Among Those Who See GLP-1 Promise in MASH Recent studies have suggested that using GLP-1 receptor agonists could have liver health benefits
PlexusDx recommends setting a weekly phone reminder for your chosen injection day, which helps you maintain a regular rhythm and prevents accidental double-dosing or missed weeks
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