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adjunct broad-spectrum SPF 30+ use each morning is mandatory, and concurrent application of potentially irritating agents (e.g., alpha-hydroxy acids or alcohol-based toners) should be minimized
Laboratory investigations may include: NF-B signaling TNF- expression IL-1 and IL-6 pathway analysis COX-2 regulation Oxidative stress mechanisms Cellular inflammatory responses These studies focus on understanding molecular signaling rather than evaluating therapeutic outcomes
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