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It is imperative to consider that intracellular lipid accumulation induces an increase in ROS production, mitochondrial dysfunction, and apoptosis, which further exacerbates the lipid excess
Glutathione itself is a substance your body produces naturally, and medical use of glutathione (or its precursor N-acetylcysteine) has a long history for example, hospitals use related treatments to help in acetaminophen overdose cases by restoring glutathione levels
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AP2/ethylene response factor (ERF) is another class of transcription factors which undergoes redox regulation (Welsch et al., 2007
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