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They help lower blood sugar, reduce appetite, and promote weight loss

The predominantly hepatic metabolism of orforglipron does, however, raise the question of whether dose adjustment is needed in hepatic impairment, an issue that was addressed in dedicated hepatic impairment studies during the clinical development program

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Strong side effects are the #1 reason why people discontinue using GLP-1s, and often, those side effects occur because of trying to push too hard, too fast, for unrealistic results