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The FDA issued a specific safety communication about compounded semaglutide dosing errors after receiving hundreds of adverse event reports
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The legal status varies by compound and jurisdiction
sarcopenia risk in older adults Refeeding syndrome risk in patients who are already nutritionally compromised Psychiatric Signals: What We Know and Do Not Know The largest psychiatric safety meta-analysis to date 80 randomized controlled trials, over 107,000 patients found that GLP-1 medications were not associated with increased risk of serious psychiatric adverse events overall, including suicidal ideation (Pierret et al., JAMA Psychiatry, 2025)
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