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KPV inhibits NF-B signalling and shows anti-inflammatory activity in rodent colitis models, with tissue selectivity mediated partly through the PepT1 transporter
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Concomitantly with the development of resistance the up-regulation of a hydrogen-peroxide inducible GST was observed that might contribute to the elimination of cytotoxic reactive metabolites containing an electrophilic moiety (Shibu et al., 2012)
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