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Further, as TP53 heterozygous deletions often co-occur with RPS15 mutation, we intercrossed Cd19 -Cre/ Rps15 MT mice with Trp53 heterozygously-deleted mice ( Trp53 del ) to generate Trp53 del / Rps15 MT co-mutant murine cohorts (Methods)
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Similarly, it leads to the downregulation of Akt, HIF-1, NF-B, and VEGF in OVCAR-3 ovarian cancer cells and suppression of TRIF/receptor interacting serine/threonine kinase 1 (RIPK1)/Fas associated via death domain (FADD), TRIF protein, caspase-8, and TLR3/IRF-3 in LNCaP and PC-3 cell lines (300, 301)
Yan X, Ma D, Li R, et al
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