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These gastrointestinal side effects typically improve within the first 2 months of treatment as physiological adaptation occurs. Expected Timeline: Weeks 1-4 : Peak intensity, especially after starting medication or dose increases Weeks 4-8 : Gradual improvement as the body adjusts to delayed gastric emptying Week 8+: 80% of cases show significant resolution Persistent cases : May require dose adjustments or alternative treatments Sulfur burps are normal on Wegovy and other GLP-1 medications as the digestive system adapts to slower gastric motility

If nausea is significant, holding at the lower dose for an additional two weeks before retrying the increase is standard practice

For example, a previous study investigated the impact of GLP-1 receptor agonists on blood ferritin levels in individuals with both T2DM and hereditary hemochromatosis