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Activation of 3-AR via Gs cAMP PKA phosphorylation of hormone-sensitive lipase (HSL) leads to: Splitting of triglycerides into free fatty acids + glycerol Release of fatty acids from adipose tissue into the blood Increased oxidation of fatty acids in mitochondria (muscle, liver) Heffernan et al
Post-menopausal women may respond more strongly to GH peptides due to lower baseline IGF-1 levels
Another study found that upregulated autophagy in aged adipocytes was due to an aging-induced decline in Rubicon, a negative regulator of autophagy [83]
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