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They're designed to treat chronic conditions, so the medicines are intended for lifelong use
We acknowledge that practice patterns and patient populations vary across settings
Facing the transition to value-based careNACHC
Then literatures reported the Ala177Val mutation has no influence on the kinetic parameters of bacterial MTHFR, but rather reduces enzyme stability and affinity for cofactor, and thus increases the tendency to form inactive enzyme via flavin dissociation, compared to the wild-type enzyme 27
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