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doi: 10.3389/fonc.2024.1414946 Received 09 April 2024 Accepted 08 July 2024 Published 22 July 2024 Volume 14 - 2024 Edited by Gaetano Gallo, Sapienza University of Rome, Italy Reviewed by Sara Claudia Barone, Sapienza University of Rome, Italy Flaminia Genualdo, Sapienza University of Rome, Italy Updates Copyright 2024 Wei, Wang, Yu, Liu and Zong

Blood was collected in heparinised syringes and placed in a tube with a mixture of DPP-4 inhibitor (Millipore, Burlington, MA, USA), heparin, EDTA and aprotonin

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Multiple Pathways to Brighter Skin Vitamin C doesnt just target pigmentationit transforms your skin through several mechanisms: Melanin inhibition : Vitamin C interacts with copper ions at tyrosinase-active sites, blocking the enzymes ability to produce melanin Antioxidant protection : It neutralizes free radicals generated by UV exposure, pollution, and environmental stressors that trigger pigmentation Collagen synthesis : Vitamin C serves as an essential cofactor for enzymes that stabilize and produce collagen, leading to firmer, more youthful skin Photoprotection : It reduces UV-induced damage by 52% and decreases sunburn cell formation by 40-60% Clinical Evidence: Proven Results Multiple studies demonstrate vitamin Cs effectiveness: A 12-week double-blind study using 10% topical vitamin C showed statistically significant reduction in photoaging and wrinkle improvement compared to placebo Daily application of 3% vitamin C for four months significantly increased dermal density A study using 25% vitamin C with a penetration enhancer reported significant melasma improvement after 16 weeks Vitamin C has been shown to replenish vitamin E levels and work synergistically with other antioxidants for enhanced photoprotection Head-to-Head Comparison: Key Differences Efficacy and Results Glutathione shows limited, inconsistent results that typically fade within months of stopping treatment