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455 Currently, several clinical trials of nanoparticle formulations for the treatment of NDDs exist

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Serious but rare risks include pancreatitis, kidney injury, gallbladder disease, and based on animal studies a potential risk of thyroid C-cell tumors

This review integrates current evidence on how brain peptides contribute to AD pathophysiology, summarizes recent progress in peptide-based therapeutic strategies and delivery platforms, and critically examines the remaining barriers to clinical translation, including bloodbrain barrier penetration, metabolic stability, off-target effects, and the need for biomarker-guided patient stratification