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Importantly, serum BDNF reflects platelet release during clotting rather than direct brain levels, so its clinical utility as a biomarker remains debated
However, the absence of NVU, BBB, and immune cells in cerebral organoids poses a significant hindrance to the application of this model
Nitric Oxide Modulation: The interaction with the NO system to protect endothelial tissue from oxidative stress and toxin-induced damage
However, IV is an in-clinic medical procedure that needs screening and supervision, whereas oral supplements are milder and self-administered
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