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They also decreased the expression of genes involved in cholesterol synthesis ( ACAT1 , SREBP-2 , HMGCR , and SQLE ), bile acid synthesis ( LXR and CYP7A1 ), and PCSK9 , while increasing the expression of genes involved in the reverse cholesterol transport pathway ( ABCA1 and SR-B1 ) and low-density lipoprotein cholesterol uptake ( LDLR )