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25th anniversary article: Supramolecular materials for regenerative medicine
Its unique mechanism, hypothesized to involve direct DNA interaction rather than surface receptor binding, sets it apart from other bioregulator peptides
FOXO4-DRI is a first-in-class senolytic peptide that selectively eliminates senescent "zombie cells" by disrupting the FOXO4-p53 interaction
They are produced from the same proglucagon precursor and are co-secreted by intestinal L-cells, but their downstream effects, drug-development trajectories, and FDA-approval status are very different
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