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Bromelain, from pineapple stems, proteolytically blocks activation of extracellular regulated kinase-2 in T cells
Clinical studies show 20% to 30% improvement in skin firmness after twelve weeks of topical use
The slight but significant effect on periosteal and appendicular skeletal growth could be seen at a much earlier postnatal age (about 23 weeks) in mice having a liver-specific double knockout of igf-1 and the ALS that display a 90% reduction in serum IGF-1 levels
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