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Investigations propose that its interaction with pituitary cells might initiate signaling cascades involving phospholipase C, which could influence intracellular calcium release and protein kinase pathways

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Beyond its cytoskeletal effects, TB-500 forms functional complexes with PINCH (particularly interesting new cysteine-histidine-rich protein) and integrin-linked kinase (ILK), activating the survival kinase Akt while inhibiting TNF--induced NF-B activation through blocking of RelA/p65 translocation