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f., Celastrol, is a pentacyclic triterpenoid compound that inhibits ototoxicity by activating heat shock protein (HSP) 32/heme oxygenase-1 (HO-1) and NF-E2-related factor-2 (Nrf2, a crucial component of the cellular oxidative stress response) in HCs in neomycin-treated mice [178]
Known internationally under the trade names Mounjaro and Zepbound, this injection is becoming highly sought after for patients who want better control over diabetes while also benefiting from its weight management properties
Additionally, 69% of participants achieved at least 10% weight loss, a threshold associated with clinically meaningful health improvements
The most recent meta-analyses grade it low-to-very-low certainty with no consistent overall increase (Liu and colleagues, meta-analysis, Ophthalmology , 2025
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