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Side Effects can be swelling, redness, tingling or numbness, drainage at the injection site, prolonged bleeding, and possibly some pain at the injection site

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Merely smokers were shown to have a higher frequency of outcomes linked to supplementation: HR 2.41 (95% CI: 1.254.64) for recurrence, HR 2.26 (95% CI: 1.254.64) for all-cause mortality, and HR 5 3.38 (95% CI: 1.1110.34) for deaths associated with initial detection of head and neck squamous cell carcinoma ( However, meta-analysis study found no apparent disparity in overall survival or the usage of vitamin E supplements during chemotherapy (HR 1.15, 95% CI 0.781.68) ( Moreover, a multicentric, double-blind, placebo-controlled, randomized trial that used the same methodology found that in patients who are suffering from stage I or II HNSCC and on radiation therapy while taking 400 IU of -tocopherol daily had a significantly higher incidence of subsequent primary malignancies (60/1000 person-years) compared to those on placebo (25/1000 person-years)