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Statistical Software 36, 148
A few small human trials have been conducted, primarily for inflammatory bowel disease
Because SAM is also required for many other methylation reactions, including gene-expression regulation, high NNMT activity draws heavily on SAM and is associated in studies with reduced NAD, a coenzyme central to cellular energy production
Researchers interested in investigating this topic should adhere to the aforementioned recommendations of 2mg/daily, subcutaneously for 15 days
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