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Fe 3+ can act as a catalase-like nanozyme to transform H 2 O 2 into O 2 , relieving the hypoxic condition in TME and boosting oxygen-based PDT and SDT

The first one includes soluble dimeric enzymes localized mainly in cytosole but certain members of this superfamily have been also identified in mitochondria (Robinson et al., 2004) or in peroxisomes (Morel et al., 2004)