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Example 5 Arg34GLP-1 (9-37) carries out the modification of terminal amino group: dissolving 1g of Boc-His (Trt) -Aib-OH in 10mL of dichloromethane, adding 0.37g of DCC, cooling to 0 , stirring for 30min, adding 0.22g of HOSu, stirring and reacting at the temperature for 12 hours, filtering, collecting filtrate, and spin-drying the filtrate to obtain a crude Boc-His (Trt) -Aib-OSu product
These lumps are not just cosmetic concerns
These two peptides are gaining serious traction in the functional medicine and performance communitiesand for good reason
Gastric emptying slows substantially on tirzepatide
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