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For multi-dose vials where the stopper is punctured multiple times over days or weeks, distilled water lacks the benzyl alcohol preservative that prevents bacterial contamination microbial growth begins within 2448 hours, producing endotoxins that interfere with research outcomes and cause injection-site reactions

However, STEP 1 extension concluded that 1-year withdrawal of semaglutide results in regain of two-thirds of prior weight loss [97], highlighting that withdrawal of semaglutide results in weight regain which may be problematic in older adults who are already using polypharmacy approaches for comorbid disease

It is used for efficient blood sugar (glucose) level regulation and glycemic control

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