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pharmacodynamic overlap possible via shared antioxidant pathways Primary concern / IV glutathione and liver-enzyme monitoring in patients on dulaglutide Monitoring recommended / LFTs at baseline and periodically when adding high-dose IV glutathione Evidence gap / no randomized controlled trial has tested the combination directly GLP-1 antioxidant effect / dulaglutide independently reduces oxidative stress markers in human studies Key guideline / ADA Standards of Care 2024 does not list glutathione as contraindicated with GLP-1 agents Bottom line / low-dose oral glutathione appears safe
Ryanodine receptors contribute to cGMP-induced late-phase LTP and CREB phosphorylation in the hippocampus
But Novartis doesnt want to just be a me-too. Gal likens the situation with GLP-1s to whats happening in China, where a burst of innovation has led to concerns about the real gains being made there and whether many drugs are simply offering incremental improvements over existing options, particularly in oncology
Usually, green poop is caused by diet (leafy greens or green food coloring) or rapid digestion
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