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Similarly encouraging are the results of a phase 2 study on the triagonist receptor agonist retatrutide showing normalization of blood glucose in 72% of subjects with prediabetes after 48 weeks of treatment compared to 22% of the control group [58]
This regulatory mechanism is central to how GLP-1RAs control energy intake, as outlined in the primary pathways for food intake inhibition shown in Figure 3
We next question whether this stomach GLP-1 was active comparing total and active GLP-1 content in the stomach with distal regions of the gut, i.e., ileum and colon
Chan, H
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