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Randomized, phase III trial of figitumumab in combination with erlotinib versus erlotinib alone in patients with nonadenocarcinoma nonsmall-cell lung cancer
The bulk of the evidence comes from animal and laboratory models
Loading phase uses higher doses (2.5-5mg) 2x weekly for 4-6 weeks to rapidly saturate tissues and initiate healing
Some individuals with significantly low B12 levels may present with minimal symptoms initially, whilst others experience pronounced manifestations
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