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Whats missing is strong, long-term evidence that long-term microdosing produces comparable outcomes in weight, blood glucose control, and reduction of cardiovascular risk
MK-677 has one big advantage: no injections
The starting dose for Zepbound is 2.5 milligrams
In trials that added it to injected insulin, basal insulin requirements fell roughly 60% to 80% while control improved. Low-blood-sugar risk therefore tracks the insulin or sulfonylurea used alongside tirzepatide more than the tirzepatide dose itself
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